3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition
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چکیده
منابع مشابه
3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.
The potential therapeutic benefits associated with Hsp90 modulation for the treatment of cancer and neurodegenerative diseases highlight the importance of identifying novel Hsp90 scaffolds. KU-398, a novobiocin analogue, and silybin were recently identified as new Hsp90 inhibitors. Consequently, a library of 3-arylcoumarin derivatives that incorporated the structural features of KU-398 and sily...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2012
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml300018e